What is Alzheimer disease? Causes,Sign and symptom and treatement || Only 24 hours in a day ||

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Today our topic is about Alzheimer's disease.

what is Alzheimer's disease? 

A Form of dementia that is characterized by slow, progressive mental deterioration.

Causes: 

             The cause of Alzheimer's disease is poorly understood. About 70% of the risk is believed to be genetic with many genes usually involved. Other risk factors include a history of head injuries, depression, or hypertension.

Symptoms 

               Start with mild forgetfulness, difficulty remembering names and faces or recent events and progress 2 memory failure, disorientation, speech disturbance, motor impairment, and aggressive behavior. It is a most common form and is distinguished by the presence of neuritic plaques (primarily in the hippocampus and parietal lobes), and neurofibirally tangles (mainly affected the pyramidal cell of the cortex). Definitive diagnoses are postmortem.

Prevention:

There is no definitive evidence to support that any particular measure is effective in preventing AD. Global studies of measures to prevent or delay the onset of AD have often produced inconsistent results. Epidemiological studies have proposed relationships between certain modifiable factors, such as diet, cardiovascular risk, pharmaceutical products, or intellectual activities among others, and a population's likelihood of developing AD. Only further research, including clinical trials, will reveal whether these factors can help to prevent AD.

Treatment:

Medication

Although cardiovascular risk factors, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with a higher risk of onset and course of AD, statins, which are cholesterol-lowering drugs, have not been effective in preventing or improving the course of the disease.

Long-term usage of non-steroidal anti-inflammatory drugs was thought in 2007 to be associated with a reduced likelihood of developing AD. Evidence also suggested the notion that NSAIDs could reduce inflammation related to amyloid plaques, but trials were suspended due to high adverse events. No prevention trial has been completed. They do not appear to be useful as a treatment, but as of 2011 were thought to be candidates as presymptomatic preventatives. Hormone replacement therapy in menopause, although previously used, may increase the risk of dementia.

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